مقایسه فعالیت مهاری تریپسین در سرم بیماران هیپرتیروئیدی و گروه شاهد (Euthyroid)

&nbsp;&nbsp;&nbsp; Alpha-1-AntiTrypsin (&alpha;1&ndash;AT) is an inhibitory &alpha;1&ndash;Protease, and belongs to &nbsp;&nbsp; complex protein of glycoprotein&nbsp; type. From the activity point of view, it&nbsp; &nbsp;&nbsp; belongs to Seiren protease inhibitors ( serpin ).There are many reports in &nbsp;&nbsp; litreture concerning a decrease in the amount of &alpha;1-AT in patients with &nbsp;&nbsp; emphysema, skin&nbsp; disorders, adult liver disease, hypothyroidism,and so on . &nbsp;&nbsp; In hypothyroidic patients along with a decrease in the amount of T3 , there &nbsp;&nbsp; is a significant decrease in the amount of &alpha;1&ndash; AT and&nbsp; consequently in the &nbsp;&nbsp; amount of TIC.Therefore , it can be expected that , in hyperthyroidic an &nbsp;&nbsp; increase in the amount of T3 results in an increase in the amounts of &alpha;1&ndash; AT &nbsp;&nbsp; and TIC. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; In this study , changes in TIC in hyperthyroidic&nbsp; patients&nbsp; in comparison &nbsp;&nbsp; with a control group was&nbsp; investigated. Measurements were performed on &nbsp;&nbsp; 72&nbsp; samples , and by&nbsp; using T- test and determination of correlation &nbsp;&nbsp; coeffiecint,the above mentioned changes were analyzed . &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The results showed that TIC in hyperthyroidic patients ( n= 42 ) had &nbsp;&nbsp; increased in comparison&nbsp; with the control group ( n = 30 ), &nbsp;&nbsp; ( n = 42 , TIC = 2.54 &plusmn; 0.414 mg/ml&nbsp;&nbsp;&nbsp; Vs&nbsp;&nbsp;&nbsp; n= 30 ,TIC= 1.87 &plusmn; 0.29 mg/ml). It was &nbsp; &nbsp;observed that in hyperthyroidic&nbsp; patients, there is a positive correlation &nbsp;&nbsp; between the amounts of T3 and TIC ( r = 0.71 , p < 0.0001). &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Therefore, it can be concluded that trypsin inhibitory capacity and &nbsp;&nbsp; &alpha;1- AT concentration had increased in hyperthyroidic patients.